MOTS-c 10mg
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring mitochondrial-derived peptide first identified in 2015. Unlike most signalling peptides, which are encoded by nuclear DNA, MOTS-c is encoded within mitochondrial DNA, making it one of a unique class of peptides known as mitochondrial-derived peptides (MDPs).
Since its discovery, MOTS-c has become an important area of metabolic and ageing research. Scientists continue to investigate its role in cellular energy regulation, mitochondrial communication and metabolic homeostasis.
Although research has expanded rapidly, MOTS-c remains an investigational peptide and is not approved as a medicine in most countries.
Structure and Origin
MOTS-c is a synthetic version of a naturally occurring peptide consisting of 16 amino acids.
Amino acid sequence:
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Unlike many peptides produced from nuclear DNA, MOTS-c originates from the mitochondrial 12S rRNA gene, making it one of the first mitochondrial peptides shown to influence cellular function outside the mitochondria.
How Does MOTS-c Work?
The exact mechanisms of MOTS-c continue to be explored. Current research suggests it functions as a signalling molecule between mitochondria and the cell nucleus, helping regulate genes involved in metabolism and cellular adaptation.
Areas currently under investigation include:
- AMPK pathway activation
- Mitochondrial communication
- Cellular energy regulation
- Glucose metabolism
- Fatty acid metabolism
- Oxidative stress response
- Nuclear gene expression during metabolic stress
These mechanisms have made MOTS-c one of the most studied peptides in mitochondrial biology.
Current Areas of Research
MOTS-c continues to be investigated across several areas of metabolic and cellular research.
Metabolic Regulation
Researchers are studying how MOTS-c may influence metabolic homeostasis and the body’s ability to adapt to changing energy demands.
Mitochondrial Function
Because it originates within mitochondrial DNA, MOTS-c is frequently investigated for its role in mitochondrial signalling and communication with the cell nucleus.
Exercise Physiology
Studies have explored whether MOTS-c influences pathways associated with exercise adaptation, endurance and skeletal muscle metabolism.
Healthy Ageing
Scientists continue investigating the relationship between MOTS-c levels, mitochondrial health and age-related biological changes.
Cellular Stress
Experimental models have examined how MOTS-c responds during periods of metabolic stress and whether it contributes to maintaining cellular function.
Why is MOTS-c Popular in Research?
Interest in MOTS-c has grown rapidly because it represents a completely different class of peptide compared with traditional growth factors or hormones.
Researchers are particularly interested in its:
- Mitochondrial origin
- Role in cellular energy regulation
- Potential influence on metabolic pathways
- Involvement in exercise and ageing research
- Broad relevance across metabolism and cell biology
As one of the newest mitochondrial-derived peptides, MOTS-c continues to generate significant scientific interest.
Storage
MOTS-c is commonly supplied as a lyophilised (freeze dried) powder to maximise long-term stability before laboratory use.
General storage recommendations include:
- Store unopened vials in a cool, dry location.
- Protect from moisture and direct sunlight.
- Refrigerate after reconstitution according to laboratory protocols.
- Avoid repeated freeze-thaw cycles where possible.
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a naturally occurring mitochondrial-derived peptide encoded by mitochondrial DNA. It is widely studied in metabolism, mitochondrial biology and ageing research.
Is MOTS-c naturally occurring?
Yes. MOTS-c is naturally produced within human mitochondria and is one of several known mitochondrial-derived peptides.
What is MOTS-c being researched for?
Current research includes metabolism, glucose regulation, mitochondrial function, exercise physiology, cellular energy production and healthy ageing.
Is MOTS-c approved as a medicine?
At present, MOTS-c remains an investigational peptide and has not been approved as a medicine in the UK or most other countries.
Why is MOTS-c supplied as a powder?
Lyophilisation improves stability during storage and transportation, allowing researchers to reconstitute the peptide immediately before laboratory use.
Disclaimer
MOTS-c is intended solely for scientific and laboratory research. It is not approved for general medical use, and ongoing research should not be interpreted as evidence of established clinical efficacy. Any research involving peptides should comply with applicable laws, regulations and institutional guidelines.
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